Butylphenyl Methylpropional
2-(4-tert-Butylbenzyl)propionaldehyde, Lilial
分子量:204.31 Cas No:80-54-6
[1] Schnuch A, Uter W, Geier J, Lessmann H, Frosch PJ (July 2007). "Sensitization to 26 fragrances to be labelled according to current European regulation. Results of the IVDK and review of the literature". Contact Dermatitis 57 (1): 1–10.

thank you very much for thisprecious information.... after i excluded allproducts that contain this ingredient, my severely deep inflammed cystic acne were cleared up significantly





Possible human immune system toxicant or allergen




The safety of butylphenyl methylpropional has been evaluated by the Research Institute for Fragrance Materials Expert Panel (REXPAN). Based on this evaluation, an International Fragrance Association (IFRA) Standard has been established. The IFRA Standard restricts the use of butylphenyl methylpropional in fragrances because of potential dermal sensitization.

A research article published in the Flavour and Fragrance Journal assessed the risk of sensitization for 26 fragrances in 5451 products from 2007 to 2009. As an estimate of sensitization risk, the sensitization exposure quotient (SEQ), was calculated as the quotient of the relative frequency of sensitization and the relative frequency of use/labelling. The SEQs (the risk) varied greatly, with butylphenyl methylpropional at the bottom of the list, indicating a very low risk of sensitization.

Since there is risk for sensitization with butylphenyl methylpropional, its presence must be indicated in the list of ingredients if the product contains more than 0.001% and is meant to be left on skin. It also must be listed if the product contains more than 0.01% and is meant to be rinsed, such as with cleansers and shampoos.

Due to the possibility of an allergic reaction, those with sensitive skin should try to butylphenyl methylpropional or perform a patch test with any product containing this ingredient.

References: Wikipedia, “Lillial”, Flavour Fragr. J., 2015, 30: 208–217, Cosmetics Info, “Butylphenyl methylpropional”, European Commission Scientific Committee on Consumer Safety “OPINION ON Butylphenyl methylpropional (BMHCA)”, 2016.

Butylphenyl Methylpropional


法令新知 |歐盟對香精香水類的新法規(EC) No 1272/2008


丁苯基甲基丙醛Butylphenyl Methylpropional,俗稱Lilial,具鈴蘭或百合花氣味,被歸類為過敏原及致癌物CMR 1B等級,此化合物存在於眾多化妝品中的香精成分,該法案增修原法條附件六(Annex VI)的第三部分,包括相關分類、標示與包裝的規範,且包括該物質本身及其混合物。

歐盟化妝品法規 EC 1223/2009禁止使用被歸類為致癌物的成分物質(CMR,致癌/致畸胎/致突變),除非列於第15款的免除名單者除外。此一有關Lilial的新分類將於2022/3/1生效,何時禁用尚未公告,但我們建議產品有使用的企業,盡早啟動取代Lilial的香精成分。



【Butylphenyl Methylpropional(丁苯基甲基丙醛)】—》歐盟已禁用!

Rating: WORST
Categories: Fragrance: Synthetic and Natural, Irritant

Butylphenyl methylpropional is a synthetic fragrance ingredient with a strong floral scent. It also goes by the name 2-(4-tert-butylbenzyl) propionaldehyde or lilial. Butylphenyl methylpropional’s use in cosmetics is restricted due to concerns over sensitivity, especially if multiple products (both personal care and household items such as air freshener) are used routinely.

This ingredient is banned for use in cosmetic and personal care products sold in European Union member countries due to potential reproductive harms in people. Worth noting is that this ingredient rarely shows up in skin care or makeup products, being more common as a fragrance additive in hair care products, perfumes and household cleansers.

In countries where butylphenyl methylpropional is still permitted for use, it must be indicated on the ingredient list if the product contains more than 0.001% and is meant to be left on skin; it also must be listed if the product contains more than 0.01% and is meant to be rinsed. This would not apply to its usage in household cleaners and laundry products.



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