Tween 80
POE (20) Sorbitan Monooleate, Polysorbate 80, Polyoxyethylene sorbitan monooleate
ポリソルベート80、モノオレイン酸ポリオキシエチレンソルビタン(20E.O.)
分子量:1310 HLB:15.7 Cas No:9005-65-6
親水性 乳化剤、可溶化剤、変性剤
[1] 張麗卿,『優質保養品選擇策略』,聯經出版社,2003/07/10。
2019-01-11

Why is it not safe?

L
2019-02-19

Not safe for fungal acne

604.822g/mol

C64H124O26
1310 g/mol

Polysorbate 80 is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid.

聚山梨酯80衍生自聚乙氧基化的脫水山梨糖醇和油酸。
該化合物中的親水基團是聚醚,也稱為聚氧乙烯基,是環氧乙烷的聚合物。
在聚山梨酸酯的命名中,聚山梨酸酯後面的數字標記是指親脂基團,在這種情況下,是油酸

https://en.wikipedia.org/wiki/Polysorbate_80

c
2021-02-12

"The safety of polysorbate 80 has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The Panel evaluated the scientific data and concluded that polysorbate 80 was safe as cosmetic ingredients.

Despite the approval of polysorbate 80 by the CIR Expert Panel, there are concerns about the presence of ethylene oxide in this ingredient. This is because the process of ethoxylation may lead to contamination with 1,4-dioxane, a potentially dangerous by-product. In fact, 1,4-dioxane is a known animal carcinogen that penetrates readily into the skin. This ingredient has also been linked with skin allergies.

The Organic Consumers Organization released a fact sheet on 1,4-dioxane based on information from the Campaign for Safe Cosmetics. The fact sheet outlines facts versus myths regarding 1,4-dioxane in personal care products. One concerning fact is that the levels of 1,4-dioxane found in many personal care products are 1,000 times higher than those found to cause cancer in animal studies. They add that according to the FDA, “Skin absorption studies demonstrated that dioxane readily penetrates animal and human skin from various types of vehicles.”

https://thedermreview.com/polysorbate-80/

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