Styrene acrylates copolymer is considered safe because there is a low likelihood of absorption of the full compound. However, contamination with the possible carcinogen styrene(苯乙烯) is a concern.
Styrene may also serve as a film-forming agent. If ingested, styrene can be toxic to red blood cells and the liver and if inhaled, it is toxic to the central nervous system. Fragranced products are often in an aerosol or spray form, allowing for inhalation. Exposure to solvents including styrene can result in an increased risk of breast cancer.
Styrene is a reasonably anticipated human carcinogen by the International Agency for Research on Cancer and by the National Toxicology Program. Styrene is also listed on the California Proposition 65 list of known carcinogens to cause cancer. The National Institute of Environmental Health Sciences reported that styrene has been linked to increased risks for cancers such as leukemia and lymphoma, and genetic damage in the white blood cells, or lymphocytes, of workers exposed to styrene. There is also some evidence for increased risk of cancer in the pancreas or esophagus among some styrene workers, but the evidence is weaker than that for lymphohematopoietic cancers.
The European Commission on Endocrine Disruption classifies styrene as a Category 1 endocrine disruptor, meaning evidence for endocrine disruption has been documented in humans and wildlife. A 2007 study on male rat offspring found that prenatal exposure to styrene at low levels obstructed genital organ development, and disrupted the endocrine systems.
Short-term exposure to styrene in humans results in mucous membrane and eye irritation, and gastrointestinal effects. Long-term exposure to styrene in humans results in effects on the central nervous system (CNS), such as headache, fatigue, weakness, and depression, CSN dysfunction, hearing loss, and nerve damage.